Seyed Mousal-Reza Hosseini; Gholam Reza Ghayour Razmgah; Mohsen Nematy; Habibollah Esmaily; Mahdi Yousefi; Mohammad Kamalinejad; Seyed Hamdollah Mosavat
Volume 20, Issue 3 , 2018, Pages 1-8
Abstract
Background: There are several therapeutic strategies available from the viewpoint of Traditional Persian Medicine (TPM) to treat hepatic diseases. Objectives: This study aimed at assessing the efficacy and safety of Nigella sativa and Melissa officinalis in patients with Non-Alcoholic Fatty Liver Disease ...
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Background: There are several therapeutic strategies available from the viewpoint of Traditional Persian Medicine (TPM) to treat hepatic diseases. Objectives: This study aimed at assessing the efficacy and safety of Nigella sativa and Melissa officinalis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). Methods: From November 2014 to May 2016, in an open-label, simple-blocked, randomized controlled clinical trial, the researchers evaluated the efficacy of Nigella sativa and Melissa officinalis compared with Orlistat capsule on the grade of fatty liver and the serumlevels of Aspartate Transaminase (AST) and Alanine Transaminase (ALT) in 50 patients with NAFLD in Iran. Results: Regarding within-group changes, a significant decrease was observed in the serum level of AST, ALT, body mass index, and grade of fatty liver in both groups after the intervention compared with baseline (P < 0.001). Repeated measures logistic regression analysis showed that there was a more significant reduction in the grade of fatty liver over the study period in the intervention group compared with the control group (0.58 ± 0.50 versus 1.51 ± 0.54, P < 0.001).Conclusion: Traditional Persian Medicine-based preparations of Nigella sativa and Melissa officinalis could reduce body weight and liver enzymes and improves the grade of fatty liver in Non-Alcoholic Fatty Liver Disease
Mahmoud Babaeian; Mohsen Naseri; Mohammad Kamalinejad; Farzaneh Ghaffari; Fatemeh Emadi; Awat Feizi; Rahmatollah Rafiei; Mohammad Mazaheri; Seyed Abbas Hasheminejad; Jae-Woo Park; Peyman Adibi
Volume 19, Issue 2 , February 2017, , Pages 1-10
Abstract
Background: Functional dyspepsia (FD) is a common gastrointestinal disease that has various treatments, including medicinal plants.Objectives: The current study aimed to investigate the effect of Mentha longifolia on relieving the symptoms and improving the quality of life (QOL) in patients with functional ...
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Background: Functional dyspepsia (FD) is a common gastrointestinal disease that has various treatments, including medicinal plants.Objectives: The current study aimed to investigate the effect of Mentha longifolia on relieving the symptoms and improving the quality of life (QOL) in patients with functional dyspepsia from the subgroup of postprandial distress syndrome (PDS). Patients and Methods: This randomized, double-blind, placebo-controlled trial was conducted in a gastroenterology clinic affiliated with Isfahan University of Medical Sciences. One hundred patients diagnosed with PDS according to the ROME III criteria were assigned to two groups: the M. longifolia capsules (three times daily for four weeks) group and the placebo group. Tools for gathering data were the FD severity scale and QOL (Persian version of the SF-36 questionnaire). Assessments of FD symptoms were obtained at baseline and also at the end of weeks 2, 4, and 12. QOL was evaluated at baseline and at the end of week 12.Results: At the end of treatment period, the M. longifolia group reported a more significant improvement in the mean severity scales of FD symptoms than the placebo group (P < 0.001). A significant difference was also observed between FD symptoms and severity scores in the two groups eight weeks after the medication was stopped. At the end of the fourth week, the greatest degrees of relief regarding epigastric bloating (70.5% vs. 21.4%, P < 0.001), epigastric fullness (68.2% vs. 31%, P < 0.001), loss of appetite (34.1% vs. 9.5%, P = 0.014) and early satiety (36.3% vs. 21.4%, P = 0.02) were observed in the control group. With M. longifolia, significant improvement in the scores of QOL was observed for the dimensions of general health, role-physical, social functioning, bodily pain, vitality, and mental health.Conclusions: This study showed the efficacy of M. longifolia in relieving PDS symptoms and improving the QOL of patients with PDS.
